Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities

Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death. Despite the similar structural folds within the critical regions of prokaryotic and eukaryot...

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Detalles Bibliográficos
Autores principales: Idowu, Temilolu, Schweizer, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745469/
https://www.ncbi.nlm.nih.gov/pubmed/29112154
http://dx.doi.org/10.3390/antibiotics6040026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745469/
https://www.ncbi.nlm.nih.gov/pubmed/29112154
http://dx.doi.org/10.3390/antibiotics6040026

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