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Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities
Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death. Despite the similar structural folds within the critical regions of prokaryotic and eukaryot...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745469/ https://www.ncbi.nlm.nih.gov/pubmed/29112154 http://dx.doi.org/10.3390/antibiotics6040026 |