Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS

OBJECTIVE: To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo. METHOD: In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes. In vivo, pharmacokinetics of celecoxib was evaluated in rats with or withou...

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Detalles Bibliográficos
Autores principales: Zheng, Xiang, Wen, Jian, Liu, Teng-hui, Ou-yang, Qiu-Geng, Cai, Jian-ping, Zhou, Hong-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745716/
https://www.ncbi.nlm.nih.gov/pubmed/29387488
http://dx.doi.org/10.1155/2017/6510232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745716/
https://www.ncbi.nlm.nih.gov/pubmed/29387488
http://dx.doi.org/10.1155/2017/6510232

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