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Activation of the Akt/mTOR signaling pathway: a potential response to long-term neuronal loss in the hippocampus after sepsis

Survivors of sepsis may suffer chronic cognitive impairment as a long-term sequela. However, the precise mechanisms of cognitive dysfunction after sepsis are not well understood. We employed the cecal ligation-and-puncture-induced septic mouse model. We observed elevated phosphorylation of Akt, mamm...

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Detalles Bibliográficos
Autores principales: Guo, Jia-nan, Tian, Lin-yu, Liu, Wen-yu, Mu, Jie, Zhou, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745837/
https://www.ncbi.nlm.nih.gov/pubmed/29239329
http://dx.doi.org/10.4103/1673-5374.219044