Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their ubiquitination and proteasomal degradation via binding to the kelch-like ECH associated protein 1 (...

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Detalles Bibliográficos
Autores principales: Jung, Byung-Jin, Yoo, Hwan-Sic, Shin, Sooyoung, Park, Young-Joon, Jeon, Sang-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2018
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746038/
https://www.ncbi.nlm.nih.gov/pubmed/29212307
http://dx.doi.org/10.4062/biomolther.2017.195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746038/
https://www.ncbi.nlm.nih.gov/pubmed/29212307
http://dx.doi.org/10.4062/biomolther.2017.195

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