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Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities
Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their ubiquitination and proteasomal degradation via binding to the kelch-like ECH associated protein 1 (...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Korean Society of Applied Pharmacology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746038/ https://www.ncbi.nlm.nih.gov/pubmed/29212307 http://dx.doi.org/10.4062/biomolther.2017.195 |