General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases

Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is curre...

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Detalles Bibliográficos
Autores principales: Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746060/
https://www.ncbi.nlm.nih.gov/pubmed/29107700
http://dx.doi.org/10.1016/j.chembiol.2017.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746060/
https://www.ncbi.nlm.nih.gov/pubmed/29107700
http://dx.doi.org/10.1016/j.chembiol.2017.09.007

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