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ISG15 silencing increases cisplatin resistance via activating p53-mediated cell DNA repair

Tumor cells frequently evolved resistance to cisplatin that greatly compromises the efficacy of chemotherapy. Identification of the mechanisms underlying drug resistance is important for developing new therapeutic approaches. ISG15 is found to be elevated in many human carcinomas and cancer cell lin...

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Detalles Bibliográficos
Autores principales: Huo, Yi, Zong, Zhaoyun, Wang, Qingtao, Zhang, Zhenyu, Deng, Haiteng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746079/
https://www.ncbi.nlm.nih.gov/pubmed/29296177
http://dx.doi.org/10.18632/oncotarget.22488