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Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS
Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for various forms of cancer and show promise in treating HIV-1 infection. However, significant limitations are persistence and whether peripheral T cell-based products can respond to malignant or infected cells that may...
Autores principales: | Zhen, Anjie, Peterson, Christopher W., Carrillo, Mayra A., Reddy, Sowmya Somashekar, Youn, Cindy S., Lam, Brianna B., Chang, Nelson Y., Martin, Heather A., Rick, Jonathan W., Kim, Jennifer, Neel, Nick C., Rezek, Valerie K., Kamata, Masakazu, Chen, Irvin S. Y., Zack, Jerome A., Kiem, Hans-Peter, Kitchen, Scott G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746250/ https://www.ncbi.nlm.nih.gov/pubmed/29284044 http://dx.doi.org/10.1371/journal.ppat.1006753 |
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