Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase

L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death. L-Asp is an important component of treatment regimens for Acute Lymphoblastic Leukemia (ALL). Sensitivity to L-Asp is due to the absence of L-Asparagin...

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Detalles Bibliográficos
Autores principales: Bertuccio, Salvatore Nicola, Serravalle, Salvatore, Astolfi, Annalisa, Lonetti, Annalisa, Indio, Valentina, Leszl, Anna, Pession, Andrea, Melchionda, Fraia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746353/
https://www.ncbi.nlm.nih.gov/pubmed/29299118
http://dx.doi.org/10.18632/oncotarget.18565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746353/
https://www.ncbi.nlm.nih.gov/pubmed/29299118
http://dx.doi.org/10.18632/oncotarget.18565

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