Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition

Resistance to targeted tyrosine kinase inhibitors (TKI) remains a challenge for the treatment of myeloid leukemias. Following treatment with TKIs, the bone marrow microenvironment has been found to harbor a small pool of surviving leukemic CD34+ progenitor cells. The long-term survival of these leuk...

Descripción completa

Detalles Bibliográficos
Autores principales: Weisberg, Ellen L., Sattler, Martin, Azab, Abdel Kareem, Eulberg, Dirk, Kruschinski, Anna, Manley, Paul W., Stone, Richard, Griffin, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746358/
https://www.ncbi.nlm.nih.gov/pubmed/29299123
http://dx.doi.org/10.18632/oncotarget.22409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746358/
https://www.ncbi.nlm.nih.gov/pubmed/29299123
http://dx.doi.org/10.18632/oncotarget.22409

Ejemplares similares