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Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition

Resistance to targeted tyrosine kinase inhibitors (TKI) remains a challenge for the treatment of myeloid leukemias. Following treatment with TKIs, the bone marrow microenvironment has been found to harbor a small pool of surviving leukemic CD34+ progenitor cells. The long-term survival of these leuk...

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Detalles Bibliográficos
Autores principales:	Weisberg, Ellen L., Sattler, Martin, Azab, Abdel Kareem, Eulberg, Dirk, Kruschinski, Anna, Manley, Paul W., Stone, Richard, Griffin, James D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746358/ https://www.ncbi.nlm.nih.gov/pubmed/29299123 http://dx.doi.org/10.18632/oncotarget.22409

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