Transforming growth factor‐β enhances Rho‐kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1

KEY POINTS: Transforming growth‐factor‐β (TGF‐β) and RhoA/Rho‐kinase are independently implicated in the airway hyper‐responsiveness associated with asthma, but how these proteins interact is not fully understood. We examined the effects of pre‐treatment with TGF‐β on expression and activity of RhoA...

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Detalles Bibliográficos
Autores principales: Shaifta, Yasin, MacKay, Charles E., Irechukwu, Nneka, O'Brien, Katie A., Wright, David B., Ward, Jeremy P. T., Knock, Greg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Respiratory
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746525/
https://www.ncbi.nlm.nih.gov/pubmed/29071730
http://dx.doi.org/10.1113/JP275033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746525/
https://www.ncbi.nlm.nih.gov/pubmed/29071730
http://dx.doi.org/10.1113/JP275033

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