Cargando…

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina

There is much debate on the adeno-associated virus (AAV) serotype that best targets specific retinal cell types and the route of surgical delivery—intravitreal or subretinal. This study compared three of the most efficacious AAV vectors known to date in a mouse model of retinal degeneration (rd1 mou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hickey, D G, Edwards, T L, Barnard, A R, Singh, M S, de Silva, S R, McClements, M E, Flannery, J G, Hankins, M W, MacLaren, R E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746594/ https://www.ncbi.nlm.nih.gov/pubmed/28872643 http://dx.doi.org/10.1038/gt.2017.85

Ejemplares similares

Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina
por: Charbel Issa, Peter, et al.
Publicado: (2013)

Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina
por: Patrício, Maria I., et al.
Publicado: (2017)

Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells
por: Dreismann, Anna K., et al.
Publicado: (2021)

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids
por: McClements, Michelle E., et al.
Publicado: (2022)

Assessment of AAV Dual Vector Safety in the Abca4(−)(/)(−) Mouse Model of Stargardt Disease
por: McClements, Michelle E., et al.
Publicado: (2020)

Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4(-/-) mouse and bipolar cells in the rd1 mouse and human retina ex-vivo
por: De Silva, Samantha R., et al.
Publicado: (2016)

Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina
por: Chandler, Laurel C., et al.
Publicado: (2021)

 Adeno-associated Virus (AAV) Dual Vector Strategies for Gene Therapy Encoding Large Transgenes
por: McClements, Michelle E., et al.
Publicado: (2017)

AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration
por: McClements, Michelle E., et al.
Publicado: (2021)

Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina
por: Salman, Ahmed, et al.
Publicado: (2021)

Accurate Quantification of AAV Vector Genomes by Quantitative PCR
por: Martinez-Fernandez de la Camara, Cristina, et al.
Publicado: (2021)

Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa
por: Fischer, M. Dominik, et al.
Publicado: (2017)

Minicircle Delivery to the Neural Retina as a Gene Therapy Approach
por: Staurenghi, Federica, et al.
Publicado: (2022)

Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances
por: McClements, Michelle E., et al.
Publicado: (2020)

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
por: Chen, Xinhong, et al.
Publicado: (2023)

AAV9 Targets Cone Photoreceptors in the Nonhuman Primate Retina
por: Vandenberghe, Luk H., et al.
Publicado: (2013)

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
por: Chen, Xinhong, et al.
Publicado: (2023)

Is subretinal AAV gene replacement still the only viable treatment option for choroideremia?
por: Han, Ruofan Connie, et al.
Publicado: (2021)

Correction: AAV9 Targets Cone Photoreceptors in the Nonhuman Primate Retina
por: Vandenberghe, Luk H., et al.
Publicado: (2013)

Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo
por: Tolmachova, Tanya, et al.
Publicado: (2013)

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis
por: Salvetti, Anna P., et al.
Publicado: (2017)

Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations
por: Salman, Ahmed, et al.
Publicado: (2022)

Tropisms of AAV for Subretinal Delivery to the Neonatal Mouse Retina and Its Application for In Vivo Rescue of Developmental Photoreceptor Disorders
por: Watanabe, Satoshi, et al.
Publicado: (2013)

RNA Editing as a Therapeutic Approach for Retinal Gene Therapy Requiring Long Coding Sequences
por: Fry, Lewis E., et al.
Publicado: (2020)

Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina
por: Koilkonda, Rajeshwari D., et al.
Publicado: (2009)

The Biological Activity of AAV Vectors for Choroideremia Gene Therapy Can Be Measured by In Vitro Prenylation of RAB6A
por: Patrício, Maria I., et al.
Publicado: (2018)

Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy
por: Chandler, Laurel C., et al.
Publicado: (2020)

Liver targeting with rAAV7: balancing tropism with immune profiles
por: Flotte, Terence R.
Publicado: (2021)

AAV2/8 Anti-angiogenic Gene Therapy Using Single-Chain Antibodies Inhibits Murine Choroidal Neovascularization
por: Hughes, Chris P., et al.
Publicado: (2018)

Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain
por: Aschauer, Dominik F., et al.
Publicado: (2013)

AAV Engineering for Improving Tropism to the Central Nervous System
por: Ghauri, Muhammad S., et al.
Publicado: (2023)

The hunt for novel AAV capsids with improved cardiac tropism
por: Miguel-dos-Santos, Rodrigo, et al.
Publicado: (2023)

Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
por: Orlans, Harry O., et al.
Publicado: (2021)

CRISPR-Cas9 DNA Base-Editing and Prime-Editing
por: Kantor, Ariel, et al.
Publicado: (2020)

Therapy Approaches for Stargardt Disease
por: Piotter, Elena, et al.
Publicado: (2021)

The Scope of Pathogenic ABCA4 Mutations Targetable by CRISPR DNA Base Editing Systems—A Systematic Review
por: Piotter, Elena, et al.
Publicado: (2022)

CRISPR DNA Base Editing Strategies for Treating Retinitis Pigmentosa Caused by Mutations in Rhodopsin
por: Kaukonen, Maria, et al.
Publicado: (2022)

New CRISPR Tools to Correct Pathogenic Mutations in Usher Syndrome
por: Major, Lauren, et al.
Publicado: (2022)

A Review of CRISPR Tools for Treating Usher Syndrome: Applicability, Safety, Efficiency, and In Vivo Delivery
por: Major, Lauren, et al.
Publicado: (2023)

Origins of direction selectivity in the primate retina
por: Kim, Yeon Jin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5ku122fk588sfch2sdeipvod8r