Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection

Immune cells are equipped with a number of receptors that recognize sterile injury and pathogens. We find that host immune cells release ATP as an inflammatory signal in response to allogeneic transplantation. ATP then acts via a feedback mechanism on the P2X7 channel to activate the NLRP3 inflammas...

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Detalles Bibliográficos
Autores principales: Amores-Iniesta, Joaquín, Barberà-Cremades, Maria, Martínez, Carlos M., Pons, José A., Revilla-Nuin, Beatriz, Martínez-Alarcón, Laura, Di Virgilio, Francesco, Parrilla, Pascual, Baroja-Mazo, Alberto, Pelegrín, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746605/
https://www.ncbi.nlm.nih.gov/pubmed/29262323
http://dx.doi.org/10.1016/j.celrep.2017.11.079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746605/
https://www.ncbi.nlm.nih.gov/pubmed/29262323
http://dx.doi.org/10.1016/j.celrep.2017.11.079

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