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Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection

Immune cells are equipped with a number of receptors that recognize sterile injury and pathogens. We find that host immune cells release ATP as an inflammatory signal in response to allogeneic transplantation. ATP then acts via a feedback mechanism on the P2X7 channel to activate the NLRP3 inflammas...

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Detalles Bibliográficos
Autores principales:	Amores-Iniesta, Joaquín, Barberà-Cremades, Maria, Martínez, Carlos M., Pons, José A., Revilla-Nuin, Beatriz, Martínez-Alarcón, Laura, Di Virgilio, Francesco, Parrilla, Pascual, Baroja-Mazo, Alberto, Pelegrín, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746605/ https://www.ncbi.nlm.nih.gov/pubmed/29262323 http://dx.doi.org/10.1016/j.celrep.2017.11.079

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