Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models

[Image: see text] Protein stabilization is fundamental to enzyme function and evolution, yet understanding the determinants of a protein’s stability remains a challenge. This is largely due to a shortage of atomically detailed models for the ensemble of relevant protein conformations and their relat...

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Detalles Bibliográficos
Autores principales: Zimmerman, Maxwell I., Hart, Kathryn M., Sibbald, Carrie A., Frederick, Thomas E., Jimah, John R., Knoverek, Catherine R., Tolia, Niraj H., Bowman, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746865/
https://www.ncbi.nlm.nih.gov/pubmed/29296672
http://dx.doi.org/10.1021/acscentsci.7b00465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746865/
https://www.ncbi.nlm.nih.gov/pubmed/29296672
http://dx.doi.org/10.1021/acscentsci.7b00465

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