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Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models
[Image: see text] Protein stabilization is fundamental to enzyme function and evolution, yet understanding the determinants of a protein’s stability remains a challenge. This is largely due to a shortage of atomically detailed models for the ensemble of relevant protein conformations and their relat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746865/ https://www.ncbi.nlm.nih.gov/pubmed/29296672 http://dx.doi.org/10.1021/acscentsci.7b00465 |