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PureCLIP: capturing target-specific protein–RNA interaction footprints from single-nucleotide CLIP-seq data

The iCLIP and eCLIP techniques facilitate the detection of protein–RNA interaction sites at high resolution, based on diagnostic events at crosslink sites. However, previous methods do not explicitly model the specifics of iCLIP and eCLIP truncation patterns and possible biases. We developed PureCLI...

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Detalles Bibliográficos
Autores principales: Krakau, Sabrina, Richard, Hugues, Marsico, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746957/
https://www.ncbi.nlm.nih.gov/pubmed/29284540
http://dx.doi.org/10.1186/s13059-017-1364-2