Cryo-EM Structures of the Human Endolysosomal TRPML3 Channel in Three Distinct States

TRPML3 channels are mainly localized to endolysosomes and play a critical role in the endocytic pathway. Their dysfunction causes deafness and pigmentation defects in mice. TRPML3 activity is inhibited by low endolysosomal pH. Here we present cryoelectron microscopy structures of human TRPML3 in the...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoyuan, Li, Minghui, Su, Deyuan, Jia, Qi, Li, Huan, Li, Xueming, Yang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747366/
https://www.ncbi.nlm.nih.gov/pubmed/29106414
http://dx.doi.org/10.1038/nsmb.3502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747366/
https://www.ncbi.nlm.nih.gov/pubmed/29106414
http://dx.doi.org/10.1038/nsmb.3502

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