p16INK4a Expression in Cervical Lesions Correlates with Histologic Grading - a Tertiary Level Medical Facility Based Retrospective Study

p16INK4a is a tumor-suppressor protein and cyclin-dependent kinase (cdk) inhibitor that blocks cdk4- and cdk6-mediated pRb phosphorylation to inhibit E2F-dependent transcription and cell-cycle progression. Because the E7 protein of high-risk HPVs inactivates pRB, the resulting overexpression of p16I...

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Detalles Bibliográficos
Autores principales: Sarma, Usha, Biswas, Ira, Das, Alakananda, Das, Gokul Chandra, Saikia, Chandan, Sarma, Bidula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747383/
https://www.ncbi.nlm.nih.gov/pubmed/29072058
http://dx.doi.org/10.22034/APJCP.2017.18.10.2643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747383/
https://www.ncbi.nlm.nih.gov/pubmed/29072058
http://dx.doi.org/10.22034/APJCP.2017.18.10.2643

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