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p16INK4a Expression in Cervical Lesions Correlates with Histologic Grading - a Tertiary Level Medical Facility Based Retrospective Study
p16INK4a is a tumor-suppressor protein and cyclin-dependent kinase (cdk) inhibitor that blocks cdk4- and cdk6-mediated pRb phosphorylation to inhibit E2F-dependent transcription and cell-cycle progression. Because the E7 protein of high-risk HPVs inactivates pRB, the resulting overexpression of p16I...
Autores principales: | Sarma, Usha, Biswas, Ira, Das, Alakananda, Das, Gokul Chandra, Saikia, Chandan, Sarma, Bidula |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747383/ https://www.ncbi.nlm.nih.gov/pubmed/29072058 http://dx.doi.org/10.22034/APJCP.2017.18.10.2643 |
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