Differentiation and cell density upregulate cytochrome c levels in megakaryoblastic cell lines: Implications for analysis of CYCS-associated thrombocytopenia

Mutations in the cytochrome c gene (CYCS) cause autosomal dominant thrombocytopenia by an unknown mechanism. While attempting to generate megakaryoblastic cell lines exogenously expressing cytochrome c variants, we discovered that endogenous cytochrome c expression increased both upon induction of d...

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Detalles Bibliográficos
Autores principales: Ong, Lily, McDonald, Kirstin O., Ledgerwood, Elizabeth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747465/
https://www.ncbi.nlm.nih.gov/pubmed/29287084
http://dx.doi.org/10.1371/journal.pone.0190433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747465/
https://www.ncbi.nlm.nih.gov/pubmed/29287084
http://dx.doi.org/10.1371/journal.pone.0190433

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