A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling

Poxviruses have evolved multiple strategies to subvert signaling by Nuclear Factor κB (NF-κB), a crucial regulator of host innate immune responses. Here, we describe an orf virus (ORFV) virion-associated protein, ORFV119, which inhibits NF-κB signaling very early in infection (≤ 30 min post infectio...

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Detalles Bibliográficos
Autores principales: Nagendraprabhu, Ponnuraj, Khatiwada, Sushil, Chaulagain, Sabal, Delhon, Gustavo, Rock, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747488/
https://www.ncbi.nlm.nih.gov/pubmed/29244863
http://dx.doi.org/10.1371/journal.ppat.1006779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747488/
https://www.ncbi.nlm.nih.gov/pubmed/29244863
http://dx.doi.org/10.1371/journal.ppat.1006779

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