Intermittent Ca(2+) signals mediated by Orai1 regulate basal T cell motility

Ca(2+) influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here, we show that inhibition of Orai1 channel activity increases average cell velocities by reducing the frequency of pauses in human T cells migrat...

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Detalles Bibliográficos
Autores principales: Dong, Tobias X, Othy, Shivashankar, Greenberg, Milton L, Jairaman, Amit, Akunwafo, Chijioke, Leverrier, Sabrina, Yu, Ying, Parker, Ian, Dynes, Joseph L, Cahalan, Michael D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747518/
https://www.ncbi.nlm.nih.gov/pubmed/29239723
http://dx.doi.org/10.7554/eLife.27827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747518/
https://www.ncbi.nlm.nih.gov/pubmed/29239723
http://dx.doi.org/10.7554/eLife.27827

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