Cargando…
Intermittent Ca(2+) signals mediated by Orai1 regulate basal T cell motility
Ca(2+) influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here, we show that inhibition of Orai1 channel activity increases average cell velocities by reducing the frequency of pauses in human T cells migrat...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747518/ https://www.ncbi.nlm.nih.gov/pubmed/29239723 http://dx.doi.org/10.7554/eLife.27827 |