Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma

BACKGROUND: In our previous study, we revealed that MEG3 was a tumor suppressor gene in retinoblastoma and inhibited proliferation of retinoblastoma cells by regulating the activity of the Wnt/β-catenin pathway. Here, we further explored the mechanism of MEG3 inactivation in retinoblastoma. METHODS:...

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Detalles Bibliográficos
Autores principales: Gao, Yali, Huang, Peng, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747938/
https://www.ncbi.nlm.nih.gov/pubmed/29287592
http://dx.doi.org/10.1186/s12967-017-1372-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747938/
https://www.ncbi.nlm.nih.gov/pubmed/29287592
http://dx.doi.org/10.1186/s12967-017-1372-8

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