Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits

The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognition(1-3), but its expression is markedly decreased in various neurological disorders associated with epileptiform activity and seizures(4-7). In Alzheimer's disease (AD) and epilepsy, both of which are acc...

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Detalles Bibliográficos
Autores principales: You, Jason C., Muralidharan, Kavitha, Park, Jin W., Petrof, Iraklis, Pyfer, Mark S., Corbett, Brian F., LaFrancois, John J., Zheng, Yi, Zhang, Xiaohong, Mohila, Carrie A., Yoshor, Daniel, Rissman, Robert A., Nestler, Eric J., Scharfman, Helen E., Chin, Jeannie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747956/
https://www.ncbi.nlm.nih.gov/pubmed/29035369
http://dx.doi.org/10.1038/nm.4413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747956/
https://www.ncbi.nlm.nih.gov/pubmed/29035369
http://dx.doi.org/10.1038/nm.4413

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