Aβ inhibits SREBP-2 activation through Akt inhibition

We previously demonstrated that oligomeric amyloid β(42) (oAβ(42)) inhibits the mevalonate pathway impairing cholesterol synthesis and protein prenylation. Enzymes of the mevalonate pathway are regulated by the transcription factor SREBP-2. Here, we show that in several neuronal types challenged wit...

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Detalles Bibliográficos
Autores principales: Mohamed, Amany, Viveiros, Anissa, Williams, Kathleen, Posse de Chaves, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748492/
https://www.ncbi.nlm.nih.gov/pubmed/29122977
http://dx.doi.org/10.1194/jlr.M076703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748492/
https://www.ncbi.nlm.nih.gov/pubmed/29122977
http://dx.doi.org/10.1194/jlr.M076703

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