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Aβ inhibits SREBP-2 activation through Akt inhibition
We previously demonstrated that oligomeric amyloid β(42) (oAβ(42)) inhibits the mevalonate pathway impairing cholesterol synthesis and protein prenylation. Enzymes of the mevalonate pathway are regulated by the transcription factor SREBP-2. Here, we show that in several neuronal types challenged wit...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748492/ https://www.ncbi.nlm.nih.gov/pubmed/29122977 http://dx.doi.org/10.1194/jlr.M076703 |