Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives

Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild-type and mutant pfDHFR with an inhibition constan...

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Detalles Bibliográficos
Autores principales: Kulatee, Suriyawut, Toochinda, Pisanu, Suksangpanomrung, Anotai, Lawtrakul, Luckhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748534/
https://www.ncbi.nlm.nih.gov/pubmed/29160825
http://dx.doi.org/10.3390/scipharm85040037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748534/
https://www.ncbi.nlm.nih.gov/pubmed/29160825
http://dx.doi.org/10.3390/scipharm85040037

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