An Archaeosome-Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Significantly Enhances Protection from Murine Melanoma

Archaeosomes constitute archaeal lipid vesicle vaccine adjuvants that evoke a strong CD8(+) T cell response to antigenic cargo. Therapeutic treatment of murine B16-ovalbumin (B16-OVA) melanoma with archaeosome-OVA eliminates small subcutaneous solid tumors; however, they eventually resurge despite a...

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Detalles Bibliográficos
Autores principales: Stark, Felicity C., Weeratna, Risini D., Deschatelets, Lise, Gurnani, Komal, Dudani, Renu, McCluskie, Michael J., Krishnan, Lakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748605/
https://www.ncbi.nlm.nih.gov/pubmed/29072624
http://dx.doi.org/10.3390/vaccines5040038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748605/
https://www.ncbi.nlm.nih.gov/pubmed/29072624
http://dx.doi.org/10.3390/vaccines5040038

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