PARP Inhibition by Flavonoids Induced Selective Cell Killing to BRCA2-Deficient Cells

High consumption of dietary flavonoids might contribute to a reduction of cancer risks. Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. We hypothesized that common flavonoids in diet naringenin, hesperet...

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Detalles Bibliográficos
Autores principales: Su, Cathy, Haskins, Alexis H., Omata, Chisato, Aizawa, Yasushi, Kato, Takamitsu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748637/
https://www.ncbi.nlm.nih.gov/pubmed/29023372
http://dx.doi.org/10.3390/ph10040080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748637/
https://www.ncbi.nlm.nih.gov/pubmed/29023372
http://dx.doi.org/10.3390/ph10040080

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