Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?

Capsaicin is the main pungent in chili peppers, one of the most commonly used spices in the world; its analgesic and anti-inflammatory properties have been proven in various cultures for centuries. It is a lipophilic substance belonging to the class of vanilloids and an agonist of the transient rece...

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Autores principales: Georgescu, Simona-Roxana, Sârbu, Maria-Isabela, Matei, Clara, Ilie, Mihaela Adriana, Caruntu, Constantin, Constantin, Carolina, Neagu, Monica, Tampa, Mircea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748815/
https://www.ncbi.nlm.nih.gov/pubmed/29258175
http://dx.doi.org/10.3390/nu9121365
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author Georgescu, Simona-Roxana
Sârbu, Maria-Isabela
Matei, Clara
Ilie, Mihaela Adriana
Caruntu, Constantin
Constantin, Carolina
Neagu, Monica
Tampa, Mircea
author_facet Georgescu, Simona-Roxana
Sârbu, Maria-Isabela
Matei, Clara
Ilie, Mihaela Adriana
Caruntu, Constantin
Constantin, Carolina
Neagu, Monica
Tampa, Mircea
author_sort Georgescu, Simona-Roxana
collection PubMed
description Capsaicin is the main pungent in chili peppers, one of the most commonly used spices in the world; its analgesic and anti-inflammatory properties have been proven in various cultures for centuries. It is a lipophilic substance belonging to the class of vanilloids and an agonist of the transient receptor potential vanilloid 1 receptor. Taking into consideration the complex neuro-immune impact of capsaicin and the potential link between inflammation and carcinogenesis, the effect of capsaicin on muco-cutaneous cancer has aroused a growing interest. The aim of this review is to look over the most recent data regarding the connection between capsaicin and muco-cutaneous cancers, with emphasis on melanoma and muco-cutaneous squamous cell carcinoma.
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spelling pubmed-57488152018-01-07 Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies? Georgescu, Simona-Roxana Sârbu, Maria-Isabela Matei, Clara Ilie, Mihaela Adriana Caruntu, Constantin Constantin, Carolina Neagu, Monica Tampa, Mircea Nutrients Review Capsaicin is the main pungent in chili peppers, one of the most commonly used spices in the world; its analgesic and anti-inflammatory properties have been proven in various cultures for centuries. It is a lipophilic substance belonging to the class of vanilloids and an agonist of the transient receptor potential vanilloid 1 receptor. Taking into consideration the complex neuro-immune impact of capsaicin and the potential link between inflammation and carcinogenesis, the effect of capsaicin on muco-cutaneous cancer has aroused a growing interest. The aim of this review is to look over the most recent data regarding the connection between capsaicin and muco-cutaneous cancers, with emphasis on melanoma and muco-cutaneous squamous cell carcinoma. MDPI 2017-12-16 /pmc/articles/PMC5748815/ /pubmed/29258175 http://dx.doi.org/10.3390/nu9121365 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Georgescu, Simona-Roxana
Sârbu, Maria-Isabela
Matei, Clara
Ilie, Mihaela Adriana
Caruntu, Constantin
Constantin, Carolina
Neagu, Monica
Tampa, Mircea
Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?
title Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?
title_full Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?
title_fullStr Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?
title_full_unstemmed Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?
title_short Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?
title_sort capsaicin: friend or foe in skin cancer and other related malignancies?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748815/
https://www.ncbi.nlm.nih.gov/pubmed/29258175
http://dx.doi.org/10.3390/nu9121365
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