Leukemia-specific delivery of mutant NOTCH1 targeted therapy

On-target drug delivery remains a challenge in cancer precision medicine; it is difficult to deliver a targeted therapy to cancer cells without incurring toxicity to normal tissues. The SERCA (sarco-endoplasmic reticulum Ca(2+) ATPase) inhibitor thapsigargin inhibits mutant NOTCH1 receptors compared...

Descripción completa

Detalles Bibliográficos
Autores principales: Roti, Giovanni, Qi, Jun, Kitara, Samuel, Sanchez-Martin, Marta, Saur Conway, Amy, Varca, Anthony C., Su, Angela, Wu, Lei, Kung, Andrew L., Ferrando, Adolfo A., Bradner, James E., Stegmaier, Kimberly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748843/
https://www.ncbi.nlm.nih.gov/pubmed/29158376
http://dx.doi.org/10.1084/jem.20151778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748843/
https://www.ncbi.nlm.nih.gov/pubmed/29158376
http://dx.doi.org/10.1084/jem.20151778

Ejemplares similares