RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207(+) dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately 60% of LCH patients harbor som...

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Detalles Bibliográficos
Autores principales: Hogstad, Brandon, Berres, Marie-Luise, Chakraborty, Rikhia, Tang, Jun, Bigenwald, Camille, Serasinghe, Madhavika, Lim, Karen Phaik Har, Lin, Howard, Man, Tsz-Kwong, Remark, Romain, Baxter, Samantha, Kana, Veronika, Jordan, Stefan, Karoulia, Zoi, Kwan, Wing-hong, Leboeuf, Marylene, Brandt, Elisa, Salmon, Helene, McClain, Kenneth, Poulikakos, Poulikos, Chipuk, Jerry, Mulder, Willem J.M., Allen, Carl E., Merad, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748846/
https://www.ncbi.nlm.nih.gov/pubmed/29263218
http://dx.doi.org/10.1084/jem.20161881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748846/
https://www.ncbi.nlm.nih.gov/pubmed/29263218
http://dx.doi.org/10.1084/jem.20161881

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