A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015

BACKGROUND: During lead identification and optimization, the advancement criteria may be driven based on scientific principles, prior experiences, and/or by examining the path paved by approved drugs. However, accessing the discovery data on physicochemical and ADME properties of the approved kinase...

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Detalles Bibliográficos
Autores principales: O’Brien, Zhihong, Moghaddam, Mehran F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748879/
https://www.ncbi.nlm.nih.gov/pubmed/28545370
http://dx.doi.org/10.2174/0929867324666170523124441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748879/
https://www.ncbi.nlm.nih.gov/pubmed/28545370
http://dx.doi.org/10.2174/0929867324666170523124441

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