Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells

Centrosome amplification is a common feature of human tumors. To survive, cancer cells cluster extra centrosomes during mitosis, avoiding the detrimental effects of multipolar divisions. However, it is unclear whether clustering requires adaptation or is inherent to all cells. Here, we show that cel...

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Detalles Bibliográficos
Autores principales: Rhys, Alexander D., Monteiro, Pedro, Smith, Christopher, Vaghela, Malti, Arnandis, Teresa, Kato, Takuya, Leitinger, Birgit, Sahai, Erik, McAinsh, Andrew, Charras, Guillaume, Godinho, Susana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748979/
https://www.ncbi.nlm.nih.gov/pubmed/29133484
http://dx.doi.org/10.1083/jcb.201704102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748979/
https://www.ncbi.nlm.nih.gov/pubmed/29133484
http://dx.doi.org/10.1083/jcb.201704102

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