Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression

Epigenetic maintenance of gene repression is essential for development. Polycomb complexes are central to this memory, but many aspects of the underlying mechanism remain unclear. LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binds Polycomb-deposited H3K27me3 and is required for repression of many Polycomb...

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Detalles Bibliográficos
Autores principales: Berry, Scott, Rosa, Stefanie, Howard, Martin, Bühler, Marc, Dean, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749160/
https://www.ncbi.nlm.nih.gov/pubmed/29212661
http://dx.doi.org/10.1101/gad.305227.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749160/
https://www.ncbi.nlm.nih.gov/pubmed/29212661
http://dx.doi.org/10.1101/gad.305227.117

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