Slightly deleterious genomic variants and transcriptome perturbations in Down syndrome embryonic selection

The majority of aneuploid fetuses are spontaneously miscarried. Nevertheless, some aneuploid individuals survive despite the strong genetic insult. Here, we investigate if the survival probability of aneuploid fetuses is affected by the genome-wide burden of slightly deleterious variants. We analyze...

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Detalles Bibliográficos
Autores principales: Popadin, Konstantin, Peischl, Stephan, Garieri, Marco, Sailani, M. Reza, Letourneau, Audrey, Santoni, Federico, Lukowski, Samuel W., Bazykin, Georgii A., Nikolaev, Sergey, Meyer, Diogo, Excoffier, Laurent, Reymond, Alexandre, Antonarakis, Stylianos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749173/
https://www.ncbi.nlm.nih.gov/pubmed/29237728
http://dx.doi.org/10.1101/gr.228411.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749173/
https://www.ncbi.nlm.nih.gov/pubmed/29237728
http://dx.doi.org/10.1101/gr.228411.117

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