Cargando…
Impact of regulatory variation across human iPSCs and differentiated cells
Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular differentiation and cell types that are otherwise difficult to access. We investigated the use of iPSCs and iPSC-derived cells to study the impact of genetic variation on gene regulation across different cell types an...
Autores principales: | Banovich, Nicholas E., Li, Yang I., Raj, Anil, Ward, Michelle C., Greenside, Peyton, Calderon, Diego, Tung, Po Yuan, Burnett, Jonathan E., Myrthil, Marsha, Thomas, Samantha M., Burrows, Courtney K., Romero, Irene Gallego, Pavlovic, Bryan J., Kundaje, Anshul, Pritchard, Jonathan K., Gilad, Yoav |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749177/ https://www.ncbi.nlm.nih.gov/pubmed/29208628 http://dx.doi.org/10.1101/gr.224436.117 |
Ejemplares similares
-
Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs
por: Burrows, Courtney K., et al.
Publicado: (2016) -
Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature
por: Thomas, Samantha M., et al.
Publicado: (2015) -
Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming
por: Nishimura, Ken, et al.
Publicado: (2014) -
Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies
por: Negoro, Ryosuke, et al.
Publicado: (2018) -
High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs
por: Merkert, Sylvia, et al.
Publicado: (2019)