Cargando…

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

In a previous report we showed that intravenous infusion of bone marrow-derived mesenchymal stem cells (MSCs) improved functional recovery after contusive spinal cord injury (SCI) in the non-immunosuppressed rat, although the MSCs themselves were not detected at the spinal cord injury (SCI) site [1]...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lankford, Karen L., Arroyo, Edgardo J., Nazimek, Katarzyna, Bryniarski, Krzysztof, Askenase, Philip W., Kocsis, Jeffery D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749801/ https://www.ncbi.nlm.nih.gov/pubmed/29293592 http://dx.doi.org/10.1371/journal.pone.0190358

Ejemplares similares

Orally Administered Exosomes Suppress Mouse Delayed-Type Hypersensitivity by Delivering miRNA-150 to Antigen-Primed Macrophage APC Targeted by Exosome-Surface Anti-Peptide Antibody Light Chains
por: Nazimek, Katarzyna, et al.
Publicado: (2020)

Antibody Light Chains Dictate the Specificity of Contact Hypersensitivity Effector Cell Suppression Mediated by Exosomes
por: Nazimek, Katarzyna, et al.
Publicado: (2018)

From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: a History of Hapten-Specific T Suppressor Factor
por: Ptak, Włodzimierz, et al.
Publicado: (2015)

Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells
por: Bryniarski, Krzysztof, et al.
Publicado: (2015)

Editorial: Extracellular vesicles as potent modulators of immunity
por: Bryniarski, Krzysztof, et al.
Publicado: (2023)

Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury
por: Nakazaki, Masahito, et al.
Publicado: (2021)

Delayed-Type Hypersensitivity Underlying Casein Allergy Is Suppressed by Extracellular Vesicles Carrying miRNA-150
por: Wąsik, Magdalena, et al.
Publicado: (2019)

Perspectives in Manipulating EVs for Therapeutic Applications: Focus on Cancer Treatment
por: Nazimek, Katarzyna, et al.
Publicado: (2020)

Increasing the Therapeutic Efficacy of Extracellular Vesicles From the Antigen-Specific Antibody and Light Chain Perspective
por: Nazimek, Katarzyna, et al.
Publicado: (2021)

Advances in the Current Understanding of the Role of Extracellular Vesicles in Allergy, Autoimmunity and Immune Regulation
por: Bryniarski, Krzysztof, et al.
Publicado: (2022)

Anti-Inflammatory Activities of Captopril and Diuretics on Macrophage Activity in Mouse Humoral Immune Response
por: Bryniarski, Paweł, et al.
Publicado: (2021)

Captopril Combined with Furosemide or Hydrochlorothiazide Affects Macrophage Functions in Mouse Contact Hypersensitivity Response
por: Bryniarski, Paweł, et al.
Publicado: (2021)

Extracellular Vesicles—Oral Therapeutics of the Future
por: Cieślik, Martyna, et al.
Publicado: (2022)

Biodelivery of therapeutic extracellular vesicles: should mononuclear phagocytes always be feared?
por: Cieślik, Martyna, et al.
Publicado: (2023)

Data supporting the understanding of modulatory function of opioid analgesics in mouse macrophage activity
por: Filipczak-Bryniarska, Iwona, et al.
Publicado: (2017)

Plasticity of the Injured Spinal Cord
por: Guérout, Nicolas
Publicado: (2021)

Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat
por: Nakazaki, Masahito, et al.
Publicado: (2023)

Immunomodulatory Activity of the Most Commonly Used Antihypertensive Drugs—Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
por: Bryniarski, Paweł, et al.
Publicado: (2022)

Immunomodulatory Potential of Diuretics
por: Bryniarski, Paweł, et al.
Publicado: (2021)

The spinal cord injured patient : comprehensive management
Publicado: (1991)

Tracheostomy in Spinal Cord Injured Patients
por: Ganuza, Javier-Romero, et al.
Publicado: (2011)

Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions
por: Markakis, Eleni A., et al.
Publicado: (2009)

Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis
por: Zhou, Yan, et al.
Publicado: (2021)

The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis
por: Li, Jing-Lu, et al.
Publicado: (2023)

Sexual rehabilitation of the spinal-cord-injured patient
Publicado: (1991)

Astrocyte transplantation for repairing the injured spinal cord
por: Zheng, Xiaolong, et al.
Publicado: (2022)

The neurovascular unit in healthy and injured spinal cord
por: Zhou, Rubing, et al.
Publicado: (2023)

Plasticity of the Injured Human Spinal Cord: Insights Revealed by Spinal Cord Functional MRI
por: Cadotte, David W., et al.
Publicado: (2012)

The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords
por: Slovinska, Lucia, et al.
Publicado: (2023)

Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes
por: Dorronsoro, Akaitz, et al.
Publicado: (2013)

The fate of proliferating cells in the injured adult spinal cord
por: McTigue, Dana M, et al.
Publicado: (2011)

Bridging the injured spinal cord with neural stem cells
por: Dulin, Jennifer N., et al.
Publicado: (2014)

ORTHOPEDIC RELATED COMORBIDITIES IN SPINAL CORD-INJURED INDIVIDUALS
por: de Oliveira, Rafaella Camilo, et al.
Publicado: (2020)

Repair of the Injured Spinal Cord by Schwann Cell Transplantation
por: Fu, Haitao, et al.
Publicado: (2022)

Integrated Neuroregenerative Techniques for Plasticity of the Injured Spinal Cord
por: Leemhuis, Erik, et al.
Publicado: (2022)

The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord
por: Sánchez-Ventura, Judith, et al.
Publicado: (2022)

RNA-seq of spinal cord from nerve-injured rats after spinal cord stimulation
por: Stephens, Kimberly E, et al.
Publicado: (2018)

Mesenchymal stromal cells integrate and form longitudinally-aligned layers when delivered to injured spinal cord via a novel fibrin scaffold
por: Hyatt, Alex J.T., et al.
Publicado: (2014)

Antibodies Enhance the Suppressive Activity of Extracellular Vesicles in Mouse Delayed-Type Hypersensitivity
por: Nazimek, Katarzyna, et al.
Publicado: (2021)

Microstructure and Mechanical Properties of PU/PLDL Sponges Intended for Grafting Injured Spinal Cord
por: Lis-Bartos, Anna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_str5mdoi7a7cudl0ivm407l8dr