Structural Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and metabolism in response to nutrients, energy levels and growth factors. It contains the atypical kinase mTOR and the RAPTOR subunit that binds to the TOS motif of substrates and regulators. mTORC1 is activated by the smal...

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Detalles Bibliográficos
Autores principales: Yang, Haijuan, Jiang, Xiaolu, Li, Buren, Yang, Hyo J., Miller, Meredith, Yang, Angela, Dhar, Ankita, Pavletich, Nikola P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750076/
https://www.ncbi.nlm.nih.gov/pubmed/29236692
http://dx.doi.org/10.1038/nature25023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750076/
https://www.ncbi.nlm.nih.gov/pubmed/29236692
http://dx.doi.org/10.1038/nature25023

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