Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein

Impaired hepatic glucose uptake (HGU) causes postprandial hyperglycemia in type 2 diabetes. Here, we show that diminished hepatic Sirt2 activity impairs HGU in obese diabetic mice. Hepatic Sirt2 overexpression increases HGU in high-fat diet (HFD)-fed obese diabetic mice and mitigates their impaired...

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Detalles Bibliográficos
Autores principales: Watanabe, Hitoshi, Inaba, Yuka, Kimura, Kumi, Matsumoto, Michihiro, Kaneko, Shuichi, Kasuga, Masato, Inoue, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750207/
https://www.ncbi.nlm.nih.gov/pubmed/29296001
http://dx.doi.org/10.1038/s41467-017-02537-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750207/
https://www.ncbi.nlm.nih.gov/pubmed/29296001
http://dx.doi.org/10.1038/s41467-017-02537-6

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