Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1

Tyrosyl-DNA phosphodiesterase (Tdp1) is a DNA 3′-end processing enzyme that repairs topoisomerase 1B-induced DNA damage. We use a new tool combining site-specific DNA–protein cross-linking with mass spectrometry to identify Tdp1 interactions with DNA. A conserved phenylalanine (F259) of Tdp1, requir...

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Detalles Bibliográficos
Autores principales: Flett, Fiona J., Ruksenaite, Emilija, Armstrong, Lee A., Bharati, Shipra, Carloni, Roberta, Morris, Elizabeth R., Mackay, C. Logan, Interthal, Heidrun, Richardson, Julia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750209/
https://www.ncbi.nlm.nih.gov/pubmed/29295983
http://dx.doi.org/10.1038/s41467-017-02530-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750209/
https://www.ncbi.nlm.nih.gov/pubmed/29295983
http://dx.doi.org/10.1038/s41467-017-02530-z

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