Cargando…

Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1

Tyrosyl-DNA phosphodiesterase (Tdp1) is a DNA 3′-end processing enzyme that repairs topoisomerase 1B-induced DNA damage. We use a new tool combining site-specific DNA–protein cross-linking with mass spectrometry to identify Tdp1 interactions with DNA. A conserved phenylalanine (F259) of Tdp1, requir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flett, Fiona J., Ruksenaite, Emilija, Armstrong, Lee A., Bharati, Shipra, Carloni, Roberta, Morris, Elizabeth R., Mackay, C. Logan, Interthal, Heidrun, Richardson, Julia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750209/ https://www.ncbi.nlm.nih.gov/pubmed/29295983 http://dx.doi.org/10.1038/s41467-017-02530-z

Ejemplares similares

The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase
por: Dexheimer, Thomas S., et al.
Publicado: (2010)

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
por: Salomatina, Oksana V., et al.
Publicado: (2021)

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
por: Huang, Shar-yin Naomi, et al.
Publicado: (2019)

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
por: Zakharenko, Alexandra L., et al.
Publicado: (2020)

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
por: Zhao, Xue Zhi, et al.
Publicado: (2022)

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
por: Lebedeva, Natalia A., et al.
Publicado: (2012)

Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin
por: Cuya, Selma M., et al.
Publicado: (2016)

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2
por: Hornyak, Peter, et al.
Publicado: (2016)

Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts
por: Brettrager, Evan J., et al.
Publicado: (2019)

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells
por: Takeishi, Ayuna, et al.
Publicado: (2020)

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction
por: Adhikari, Sanjay, et al.
Publicado: (2012)

Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors
por: Gushchina, I.V., et al.
Publicado: (2017)

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols
por: Dyrkheeva, Nadezhda, et al.
Publicado: (2020)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
por: Salomatina, Oksana V., et al.
Publicado: (2018)

Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)
por: Schellenberg, Matthew J., et al.
Publicado: (2012)

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
por: Gladkova, Elizaveta D., et al.
Publicado: (2020)

Tyrosyl-DNA Phosphodiesterase I N-Terminal Domain Modifications and Interactions Regulate Cellular Function
por: Brettrager, Evan J., et al.
Publicado: (2019)

Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan
por: Chepanova, A. A., et al.
Publicado: (2023)

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
por: Walker, Sarah, et al.
Publicado: (2014)

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?
por: Cui, Xiuji, et al.
Publicado: (2015)

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents
por: Wang, Wenjie, et al.
Publicado: (2019)

N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells
por: Brettrager, Evan J., et al.
Publicado: (2023)

Structure–function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana
por: Kim, Hoyeun, et al.
Publicado: (2012)

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding
por: Shimizu, Naoto, et al.
Publicado: (2023)

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
por: Zhou, Tong, et al.
Publicado: (2005)

Poly(ADP-ribose)polymerase 1 stimulates the AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
por: Lebedeva, Natalia A., et al.
Publicado: (2015)

The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses
por: Sabatini, Maria Elisa, et al.
Publicado: (2017)

Plant TDP1 (Tyrosyl-DNA Phosphodiesterase 1): A Phylogenetic Perspective and Gene Expression Data Mining
por: Mutti, Giacomo, et al.
Publicado: (2020)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2021)

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan
por: Khomenko, Tatyana M., et al.
Publicado: (2023)

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
por: Lebedeva, Natalia A., et al.
Publicado: (2021)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA–protein crosslinks in vivo
por: Anticevic, Ivan, et al.
Publicado: (2023)

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
por: Komarova, Anastasia O., et al.
Publicado: (2018)

Characterization of N- and C-terminal endogenously tagged Tyrosyl-DNA phosphodiesterase 2 (TDPT-1) C. elegans strains
por: Bhandari, Nirajan, et al.
Publicado: (2022)

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification
por: Zhao, Xue Zhi, et al.
Publicado: (2023)

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus
por: Rashid, Ishtiaque, et al.
Publicado: (2021)

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
por: Zeng, Zhihong, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_tlol19gat87egvhotjacnihm95