Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we elucidate the impact of evolutionary and immune-related forces on editing the tumor in a mouse model for hypermutated...

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Detalles Bibliográficos
Autores principales: Efremova, Mirjana, Rieder, Dietmar, Klepsch, Victoria, Charoentong, Pornpimol, Finotello, Francesca, Hackl, Hubert, Hermann-Kleiter, Natascha, Löwer, Martin, Baier, Gottfried, Krogsdam, Anne, Trajanoski, Zlatko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750210/
https://www.ncbi.nlm.nih.gov/pubmed/29296022
http://dx.doi.org/10.1038/s41467-017-02424-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750210/
https://www.ncbi.nlm.nih.gov/pubmed/29296022
http://dx.doi.org/10.1038/s41467-017-02424-0

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