Cargando…
Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
The hallmark of many bacterial infections is pain. The underlying mechanisms of pain during live pathogen invasion are not well understood. Here, we elucidate key molecular mechanisms of pain produced during live methicillin-resistant Staphylococcus aureus (MRSA) infection. We show that spontaneous...
Autores principales: | Blake, Kimbria J., Baral, Pankaj, Voisin, Tiphaine, Lubkin, Ashira, Pinho-Ribeiro, Felipe Almeida, Adams, Kelsey L., Roberson, David P., Ma, Yuxin C., Otto, Michael, Woolf, Clifford J., Torres, Victor J., Chiu, Isaac M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750211/ https://www.ncbi.nlm.nih.gov/pubmed/29295977 http://dx.doi.org/10.1038/s41467-017-02448-6 |
Ejemplares similares
-
Comparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels
por: Nakagawa, Hiroshi, et al.
Publicado: (2013) -
Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats
por: Yoon, Jeong-Ho, et al.
Publicado: (2018) -
Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314
por: Woodruff, Alan G., et al.
Publicado: (2019) -
Acid Solution Is a Suitable Medium for Introducing QX-314 into Nociceptors through TRPV1 Channels to Produce Sensory-Specific Analgesic Effects
por: Liu, He, et al.
Publicado: (2011) -
The Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats
por: Zhao, Yi, et al.
Publicado: (2014)