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TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical psoriasis. The pathogenesis of this side effect and its distinction from classical psoriasis remain unknown. Here we sh...

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Detalles Bibliográficos
Autores principales: Conrad, Curdin, Di Domizio, Jeremy, Mylonas, Alessio, Belkhodja, Cyrine, Demaria, Olivier, Navarini, Alexander A., Lapointe, Anne-Karine, French, Lars E., Vernez, Maxime, Gilliet, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750213/
https://www.ncbi.nlm.nih.gov/pubmed/29295985
http://dx.doi.org/10.1038/s41467-017-02466-4