Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Cancer cells undergo a shift in metabolism where they become reliant on nutrients such as the amino-acid glutamine. Glutamine enters the cell via the alanine/serine/cysteine transporter 2 (ASCT2) that is upregulated in several cancers to maintain an increased supply of this nutrient and are therefor...

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Detalles Bibliográficos
Autores principales: Scopelliti, Amanda J, Font, Josep, Vandenberg, Robert J, Boudker, Olga, Ryan, Renae M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750217/
https://www.ncbi.nlm.nih.gov/pubmed/29295993
http://dx.doi.org/10.1038/s41467-017-02444-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750217/
https://www.ncbi.nlm.nih.gov/pubmed/29295993
http://dx.doi.org/10.1038/s41467-017-02444-w

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